Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers

Abstract Toxic protein aggregates can spread among neurons to promote human neurodegenerative Futon Mattresses disease pathology.We found that in C.elegans touch neurons intermediate filament proteins IFD-1 and IFD-2 associate with aggresome-like organelles and are required cell-autonomously for efficient production of neuronal exophers, giant vesi

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A Proposed Novel Approach in Estimation of Unbiased Community Rarity Using the Locked Matrix and Tsallis Entropy

The present study offers a new approach to measure unbiased rarity at the community level r q*.In this approach, the locked data matrix (matrix H) and the survey data matrix of the communities (matrix A) play the essential roles.q* q* The core equations of this approach are Tsallis entropy (qS) and bias-corrected Tsallis cap entropy q S.From the va

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Influenza vaccination for patients with chronic obstructive pulmonary disease: understanding immunogenicity, efficacy and effectiveness

Influenza infection is an important cause of global mortality and morbidity with the greatest impact on older people and those with chronic disease.Patients with chronic obstructive pulmonary disease (COPD) are particularly vulnerable to influenza, with evidence for increased incidence and severity of infection.In this patient group influenza is as

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Transcriptome analysis of mRNA and microRNAs in intramuscular fat tissues of castrated and intact male Chinese Qinchuan cattle.

Intramuscular fat (IMF) is known to enhance beef palatability and can be markedly increased by castration.However, there is little understanding of the molecular mechanism underlying the IMF cap deposition after castration of beef cattle.We hypothesize that genetic regulators function differently in IMF from bulls and steers.Therefore, after detect

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